Molecular Diversity and Libraries of Structures: Synthesis and Screening

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Title:Molecular Diversity and Libraries of Structures: Synthesis and Screening
Creators:
Rinnová, Markéta
Lebl, Michal
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 61, 2, pp. 171-231
Uncontrolled Keywords:Biological libraries, Multiple syntheses, Solid phase syntheses, Combinatorial libraries

Abstract

Library, or molecular diversity, approaches are a progressive tool in contemporary investigation of biological interactions and drug discovery. All library approaches include certain degree of rationality and cannot be therefore classified as random or irrational techniques. Reviewed techniques are complementary to so called "rational design"; they can serve either as a tool to generate a lead, or, on the other hand, to optimize a "designed" lead by rapid evaluation of structure-activity relationships. Combinatorial approaches are based on either a random or multiple principle which enables production of large number of diverse molecular structures that can be simultaneously screened and evaluated in a biological assay to find an optimal interacting molecule.

Title:Molecular Diversity and Libraries of Structures: Synthesis and Screening
Creators:
Rinnová, Markéta
Lebl, Michal
Uncontrolled Keywords:Biological libraries, Multiple syntheses, Solid phase syntheses, Combinatorial libraries
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:61
Number:2
Page Range:pp. 171-231
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19960171UNSPECIFIED
ID Code:925
Item Type:Article
Deposited On:06 Feb 2009 17:05
Last Modified:06 Feb 2009 16:05

Citation

Rinnová, Markéta; Lebl, Michal (1996) Molecular Diversity and Libraries of Structures: Synthesis and Screening. Collection of Czechoslovak Chemical Communications, 61 (2). pp. 171-231. ISSN 0010-0765

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