Conformational Features of a Synthetic Cyclic Peptide Corresponding to the Complete V3 Loop of the ELI HIV-1 Strain in Water

[img]PDF - Authorized users only
Language: English
71Kb
Title:Conformational Features of a Synthetic Cyclic Peptide Corresponding to the Complete V3 Loop of the ELI HIV-1 Strain in Water
Creators:
Vranken, Wim F.
Buděšínský, Miloš
Fant, Franky
Boulez, Kris
Gras-Masse, Hélène
Borremans, Frans A. M.
Journal or Publication Title:
Collection of Czechoslovak Chemical Communications, 61, 5, pp. 742-750
Uncontrolled Keywords:HIV-1, 2D NMR, Conformation in water, gp120, ELI sequence V3 loop

Abstract

The disulfide bridge closed cyclic peptide corresponding to the whole V3 loop of the envelope protein gp120 of the ELI HIV-1 strain was synthesized and examined by proton 2D NMR spectroscopy in water. Although the peptide is mainly conformationally flexible, a turn appears to be present at an N-terminal glycosylation site, while in the C-terminal half of the peptide the data point toward nascent helical structures. Similar conformational preferences in aqueous solution were observed in other V3 loop peptides, especially for the Ile28-Gly30 tripeptide part.

Title:Conformational Features of a Synthetic Cyclic Peptide Corresponding to the Complete V3 Loop of the ELI HIV-1 Strain in Water
Creators:
Vranken, Wim F.
Buděšínský, Miloš
Fant, Franky
Boulez, Kris
Gras-Masse, Hélène
Borremans, Frans A. M.
Uncontrolled Keywords:HIV-1, 2D NMR, Conformation in water, gp120, ELI sequence V3 loop
Divisions:Life and Chemical Sciences > Institute of Organic Chemistry and Biochemistry > Collection of Czechoslovak Chemical Communications
Journal or Publication Title:Collection of Czechoslovak Chemical Communications
Volume:61
Number:5
Page Range:pp. 742-750
ISSN:0010-0765
E-ISSN:1212-6950
Publisher:Institute of Organic Chemistry and Biochemistry
Related URLs:
URLURL Type
http://dx.doi.org/10.1135/cccc19960742UNSPECIFIED
ID Code:974
Item Type:Article
Deposited On:06 Feb 2009 17:05
Last Modified:06 Feb 2009 16:05

Citation

Vranken, Wim F.; Buděšínský, Miloš; Fant, Franky; Boulez, Kris; Gras-Masse, Hélène; Borremans, Frans A. M. (1996) Conformational Features of a Synthetic Cyclic Peptide Corresponding to the Complete V3 Loop of the ELI HIV-1 Strain in Water. Collection of Czechoslovak Chemical Communications, 61 (5). pp. 742-750. ISSN 0010-0765

Repository Staff Only: item control page